# Reading list

> Reading list — Belle Telehealth — The Belle Telehealth reading list gathers published GHK-Cu work on skin measurements, collagen, gene expression, penetration and a hair trial.

Skin reviews, cell experiments, a penetration study and a human hair-count trial gathered in one place.

## Skin and topical delivery

The [topical anti-wrinkle review](https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/) gives the formulation problem plenty of attention. The [skin-regeneration review](https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/) brings together clinical skin outcomes and cell work. For a physical view of delivery, the [human skin penetration experiment](https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/) measures copper in excised tissue.

For a concrete picture of material crossing skin, I’d open the penetration paper first. The reviews open the wider appearance-related questions.

## Cells and follicles

The [fibroblast collagen experiment](https://pubmed.ncbi.nlm.nih.gov/3169264/) provides a specific cell result. The [tissue-remodeling review](https://pubmed.ncbi.nlm.nih.gov/18644225/) and [gene-data review](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) give that narrow finding a much wider biological setting.

The [hair-count trial](https://pmc.ncbi.nlm.nih.gov/articles/PMC4969472/) tests a combination formulation in men. I’d read it alongside the skin reviews for the pleasure of encountering a different endpoint, with its own small numerical surprise.

## References

[1] Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ https://pubmed.ncbi.nlm.nih.gov/3169264/
[2] The human tri-peptide GHK and tissue remodeling https://pubmed.ncbi.nlm.nih.gov/18644225/
[3] Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/
[4] Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/
[5] GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
[6] Human skin penetration of a copper tripeptide in vitro as a function of skin layer https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/
[7] Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth https://pmc.ncbi.nlm.nih.gov/articles/PMC4969472/

---

Belle Telehealth houses my close-ups of published research on skin; it operates as an editorial site, with no care or retail business and no medical advice.